Abstract Search

ea0099rc3.5 | Rapid Communications 3: Adrenal and Cardiovascular Endocrinology | Part I | ECE2024

The saline infusion test with mass spectrometric measurements of aldosterone in patients tested for primary aldosteronism

Pamporaki Christina , Remde Hanna , Constantinescu Georgiana , Kuerzinger Lydia , Fuss Carmina Teresa , Peitzsch Mirko , Schulze Manuel , Lee Myron , Yang Jun , Mueller Lisa , Williams Tracy Ann , Reincke Martin , Gruber Sven , Beuschlein Felix , Lenders Jacques , Eisenhofer Graeme

Background: Confirmation of primary aldosteronism (PA) with the saline infusion test (SIT) requires accurate measurements of plasma aldosterone, best achieved by mass spectrometry. Performance of the test and appropriate cut-offs remain inadequately defined.Design and methods: This prospective multicenter cohort study involved 451 patients with suspected PA who underwent a seated SIT. Among these, there were 90 and 76 in whom PA was respectively confirmed and excluded based on...

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ea0099p16 | Adrenal and Cardiovascular Endocrinology | ECE2024

False-positive and false-negative results during screening, confirmatory testing and subtyping for suspected primary aldosteronism: lessons from Prosaldo

Constantinescu Andreea Georgiana , Pamporaki Christina , Alessi Francesco , Passauer Jens , Remde Hanna , Kuerzinger Lydia , Fuss CarminaTeresa , Schulze Manuel , Peitzsch Mirko , Horvath Andrea , Yang Jun , Bruedgam Denise , Williams TracyAnn , Reincke Martin , Gruber Sven , Beuschlein Felix , Lenders Jacques , Eisenhofer Graeme

Background: Diagnostic stratification of patients with suspected primary aldosteronism (PA) is a multistep process reliant on tests that are not infallible. Only through prospective studies can diagnostic accuracy be appropriately assessed.Methods: The PROSALDO trial enrolled 819 patients between 2019 and 2023 to assess steroid profiles against routine tests for diagnostic stratification. A combination of these tests and outcome assessments, including me...

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ea0099oc11.4 | Oral Communications 11: Adrenal and Cardiovascular Endocrinology | Part II | ECE2024

Machine learning-based differentiation of uni- and bilateral primary aldosteronism using circulating microRNA combinations

Vekony Balint , Nyirő Gabor , Herold Zoltan , Fekete Janos , Ceccato Filiipo , Gruber Sven , Kurzinger Lydia , Parasiliti-Caprino Mirko , Szucs Nikolette , Szeredas Balint , Nazri Siti Khadija Syed Mohammed , Fell Vanessa , Bassiony Mohamed , Azizan Elena A B Aisha , Bancos Irina , Beuschlein Felix , Igaz Peter

Background: Primary aldosteronism (PA) is the most prevalent cause of secondary hypertension. Its two main clinical forms are unilateral adenoma (APA) and bilateral hyperplasia (BAH), which require markedly different medical treatments, so differentiating between the two is of utmost clinical importance. The current gold standard method for this is adrenal vein sampling (AVS), the application of which is hindered by limited availability and high skill requirements.AimOur goal ...

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Endocrine Abstracts

The saline infusion test with mass spectrometric measurements of aldosterone in patients tested for primary aldosteronism

False-positive and false-negative results during screening, confirmatory testing and subtyping for suspected primary aldosteronism: lessons from Prosaldo

Machine learning-based differentiation of uni- and bilateral primary aldosteronism using circulating microRNA combinations

BiosciAbstracts